Global Alliance for Rabies Control still says there are at least 120 times more rabies deaths than found by 18 years of annual body counts
NEW DELHI, India––Mad dogs and rabies are finally following Englishmen out of India, approximately 165 years after an 1857 New York Times report indicated that the disease had apparently reached India with fighting dogs brought from Cyprus by British troops, and 75 years after English military occupation ended.
New national rabies survey data from the Central Bureau of Health Intelligence, the Indian equivalent of the U.S. Centers for Disease Control & Prevention, shows for the 18th consecutive year that India––and therefore the world––has magnitudes of order fewer human rabies deaths than the Scotland-based Global Alliance for Rabies Control and other agencies raising funds for rabies control commonly claim.
Because India is believed by the World Health Organization and the Global Alliance for Rabies Control to have the vast majority of human rabies deaths worldwide, the new Indian data suggests that the overall contribution of rabies to human disease mortality has been greatly exaggerated.
Indeed, if the global human death toll from rabies is proportionate to the rabies death rate in India, there may be as few as 305 verifiable human deaths per year from rabies worldwide.
Numbers validate Animal Birth Control program
The most important implication of the new data, however, and of the 17 previous annual surveys showing similar, is that the Animal Birth Control anti-rabies programs promoted since 1997 by the Animal Welfare Board of India, funded since 2003 by the Indian federal government, are succeeding spectacularly in eliminating “rabies menace,” if not all “dog menace,” including attacks by non-rabid dogs, which have soared in India in recent years.
Also succeeding spectacularly is the British-funded nonprofit Mission Rabies project, which since mid-2013 has vaccinated nearly 1.4 million dogs in target areas surrounding recent confirmed rabies cases.
(See Mission Rabies vaccinates 60,000 dogs in 10 Indian cities in 30 days.)
Rabies deaths in India down to 55 in 2020
Only 55 people died from rabies in India in 2020, according to the 2021 Indian national rabies death survey recently published by the Central Bureau of Health Intelligence.
The Central Bureau of Health Intelligence is the Indian equivalent of the U.S. Centers for Disease Control & Prevention.
The Central Bureau of Health Intelligence survey showed for the 19th consecutive year that the Indian rabies case load is magnitudes of order less than is often asserted by the World Organization for Animal Health, the World Health Organization, and the Global Alliance for Rabies Control, none of which have hard data to support their claims.
Actual annual rabies death totals reported by the Central Bureau of Health Intelligence over the eight years preceding the all-time low count of 55 were 132 human rabies deaths in 2013; 125 in 2014, up from an initial report of 98 due to late-arriving case reports; 113 in 2015; 86 in 2016; 97 in 2017; and 116 in 2018; and 105 in 2019, for an average of 92 per year.
For the years 2005-2012, India averaged 249 rabies deaths per year, according to Central Bureau of Health Intelligence data.
That the Indian rabies death toll is markedly down has been widely recognized for many years among people who actually look at the numbers.
Summarized the June 14, 2017 edition of the Times of India, lumping together data from 2014, 2015, and 2016, “As per the figures given by the Union Health Ministry, India has reported 324 fatalities due to animal bite.”
(See New data shows decline of rabies in India.)
“In need of elucidation”
Cautiously commented Program for Monitoring Emerging Diseases senior technical editor Maria Jacobs, from Zurich, Switzerland, “India’s human rabies statistics have been subject to discussions in the past, and are certainly in need of elucidation. The official annual number of human fatalities has been counted in 3-figure numbers, while 5-figure numbers are generally cited by international organizations.”
The Global Alliance for Rabies Control, based in Edinburgh, Scotland, continues to allege persistent under-reporting of rabies in India to a degree almost unparalleled for recognized diseases in the annals of medicine.
The chief exception would be reporting of HIV infection in nations with strong taboos and even severe criminal penalties against promiscuity and homosexuality.
Theoretical & extrapolated data
Despite the evidence amassed since 2005 by the Central Bureau of Health Intelligence, the Global Alliance for Rabies Control [GARC] argues that the actual Indian human rabies death numbers should be in the range of 12,700 to 20,565.
The Global Alliance for Rabies Control bases this projected case range on theoretical and extrapolated data, rather than confirmed body counts.
Baseline data from 1911
Much of the input data for the extrapolated numbers favored by GARC appears to originate with a national survey of government hospitals published in 1911 by doctors David Semple and William F. Harvey, done just before they introduced post-rabies exposure vaccination to India.
The same 1911 survey furnished the baseline data still used for projections of rabies deaths in Pakistan, Bangladesh, Nepal, Afghanistan, and Sri Lanka, all of which were also then under British administration as part of colonial British India.
The Central Bureau of Health Intelligence uses essentially the same survey method, but expedited by the use of electronic communications.
2003 study found 235 human rabies deaths
Studies funded by the World Health Organization have supported both the high and the low numbers––the high number coming from literature reviews tending to recycle the older estimates, the low number from an actual hospital study done in 2003 by M.K. Sudarshan, director of the Kempegowda Institute of Medical Sciences in Bangalore.
Sudarshan found 235 human rabies deaths for the whole of India.
Improved access to treatment needed
Whatever the actual number of human rabies deaths in India, it could plummet further just by improving access to state-of-the-art post-exposure treatment, according to an August 2016 audit of 128 suspected human rabies cases by scientists at the National Institute of Mental Health & Neurosciences in Bangalore.
The 2016 National Institute of Mental Health & Neurosciences recommendations appear to have been implemented to some extent, as shown by the decline in rabies deaths, but the extent of implementation is difficult to quantify, in part because reported rabies cases have become so few: 28 of the 36 Indian states reported none at all in 2020.
Explained The Telegraph of post-exposure rabies treatment: “Immunization procedures seek to exploit the slow pace at which the rabies virus spreads through the body. The virus infects only nerve cells, and can take anywhere from days to months to move from the site of the bite [transmitting the virus from a rabid animal] to the brain, where it causes inflammation, or encephalitis, that leads to death.”
Locally manufactured descendants of the post-exposure vaccines developed by Semple and Harvey have long been widely available in India––but not always where and when they were most urgently needed.
The major difference between then and now is that the vaccines produced by Semple and Harvey were cultivated by injecting live rabies virus into sheeps’ brains, a process which made accepting post-exposure vaccination unacceptable to some Jains and strictly observant Hindus and Buddhists, whose religious beliefs eschew using any animal products or byproducts.
“Current vaccines are produced by injecting killed rabies virus into chicken embryos or into cultures of various cells,” explains Colorado State University professor emeritus of veterinary medicine and biomedical science Charles Calisher.
“The final products produce immune responses in humans, pets, and livestock, albeit multiple doses are sometimes used. This production process is unacceptable to some Jains, but generally accepted by Hindus, Buddhists, and most Jains.
“The vaccine of choice,” however, “remains that produced in human diploid cells,” rarely available in India, while “the chicken embryo vaccine and other forms are also available and may be less expensive.”
Hospitals don’t stock enough vaccine
Rabies post-exposure vaccinations are by law supposed to be provided by Indian government hospitals free of charge to victims of bites by suspected rabid animals.
Unfortunately, as Shivani Azad of The Times of India reported from Dehradun on June 6, 2017, echoing countless similar reports from around India in recent years, government hospitals often fail to keep supplies of post-exposure vaccine in stock sufficient to keep pace with unexpected surges in animal bites.
Animal Birth Control brought more bites, not fewer
In Dehradun the numbers of dog and monkey bites rose 50% in early 2017 over 2016, coinciding with the success of a start-up Animal Birth Control program in sterilizing about 7,000 of the estimated 20,000 free-roaming dogs in the city.
This was not an unusual or unforseeable result, since sterilized, vaccinated dogs are more likely to become adopted as outdoor pets by regular feeders, and become territorial in defense of their feeding locations.
At the same time, reduced street dog populations are less able to form spontaneous packs to roust marauding macaques, who can become quite aggressive. On July 15, 2022, for example, macaques killed a four-month-old boy in Bareilly, Uttar Pradesh, by grabbing him from his father, Nirdesh Upadhyay, 25, and throwing the boy from a rooftop.
Hundreds of Indian cities have experienced similar surges in dog bites and macaque invasions in the wake of successful Animal Birth Control programs, even as rabies cases fall to zero.
Little coordination among animal & human health agencies
Unfortunately, Animal Birth Control programs are rarely if ever coordinated with government hospital administrations.
Meanwhile, with any rabies still at large, post-bite vaccination is still essential.
Currently in Dehradun, and recently in many other cities, “For most patients, the ordeal of getting an anti-rabies vaccine is worse than the trauma of being attacked,” Shivani Azad wrote, “with several city hospitals failing to provide vaccines. In the past two weeks, none of the government hospitals had a stock of anti-rabies injections,” forcing bite victims to turn to relatively expensive for-profit medical service providers.
RIG could save half of victims
Explained The Telegraph, “current standard treatment “requires the bite victims to be injected as soon as possible with rabies immunoglobulin (RIG), a substance that helps neutralize the virus near the bite wounds in the early hours after the bite. This is followed by four or five doses of the anti-rabies vaccine to be taken on the day of the bite,” if possible, “and on the 3rd, 7th, 14th and 28th days after the bite.
“But RIG is not widely available in India,” The Telegraph observed, “and a significant proportion of patients do not receive it.”
The National Institute of Mental Health & Neurosciences found that 13 of the 24 patients in the study who developed laboratory-confirmed rabies had received fewer than half of the recommended number of post-bite vaccinations. At least 10 of the 24 rabies victims had not received RIG at all.
“All but 3 of the 24 patients were dog bite victims,” The Telegraph added. “The exceptions were a 45-year-old woman bitten on her toe by a mongoose, a 15-year-old girl scratched on her nose by a cat, and a 47-year-old man bitten on his hand by a monkey.”
The National Institute of Mental Health & Neurosciences found five patients who had apparently survived rabies infections since 2011, all with severe brain damage.
But the case reporting in India is often somewhat suspect, tending to identify rabies as the cause of very high fevers leading to mental impairment or death, rather than much more common yet less widely known mosquito-borne diseases such as Japanese encephalitis, which can produce lookalike symptoms.
For example, rabies rarely takes longer than two months to incubate and become lethal to infected humans.
Nonetheless, the June 15, 2017 edition of The Times of India declared that “A scratch from a pet dog 11 years ago led to the death of a 45-year-old Army jawan [soldier] in Pune’s Command Hospital” on March 31, 2017.
Though the bite was ascribed to an incident in 2006, victims of bat rabies and mosquito-borne diseases often do not know they have been bitten.
Posted Program for Monitoring Emerging Diseases animal disease and zoonoses moderator Arnon Shimshony, “The following commentary by ProMED moderator Eskild Petersen, published in response to a human case in Nepal said to had undergone a 53 year incubation period, is applicable here: ‘Such incubation period is so long that a healthy bit of skepticism seems appropriate.
At a minimum, we need two additional pieces of evidence: 1) viral isolation as a proof of diagnosis; and 2) genetic evaluation of the virus to determine its origin, such as dog or bat, etc. Even if it is of dog origin, a minor exposure over such a long duration could have been forgotten, such as petting a dog with saliva on its fur.’
Non-rabid fatalities surge
Ironically, as the threat of rabies recedes from India and the Indian street dog population declines, as in Dehradun, the threat of non-rabid attack from insecurely kept owned dogs has exploded.
(See Pit bull attack death streak reaches nine in nine days.)
Although pit bulls have been identified as inflicting two non-rabid fatal attacks in India thus far in 2022, most Indian dog attack reportage omits information about the breeds of the dogs involved, instead attributing attacks to “strays” who are presumed to be the free-roaming mongrels long ubiquitous throughout the nation.
Harrell Guy Graham says
Immediately after being bitten, washing the wound for at least 10 minutes with soap and water will remove many virus particles if the animal has rabies. Applying some iodine and hydrogen peroxide will kill other pathogens. Rabies is a slow moving virus and washing the wound like this is much, much more important than rushing to the hospital when bitten because a rabies bite is not a medical emergency, unless one—especially a child–is bitten on the face and/or neck, in which case you still want to wash the wound before rushing to the hospital. At the hospital, you should make sure that in addition to injections you or the hospital staff washes the wound some more. Never rely on vaccinations alone to protect you from rabies. Yet no one—even those previously unvaccinated— who has received prompt post-exposure treatment has ever died from rabies.
Merritt Clifton says
Further to Harrell Graham’s recommendations, the Lady Gertrude Stock and friends in 1891 met in London to form the National Canine Defence League, now known as Dogs Trust, specifically to promote humane rabies control. Their first project was to begin immediately locating dog bite victims and washing their wounds–a seemingly simple, obvious procedure which until then had never been promoted in a systematic manner. The NCDL also began dispatching physicians to investigate all reports of rabies outbreaks. Many proved to be misreported, involving bites by healthy dogs and/or dogs who were ill from other diseases. The third NCDL anti-rabies activity was campaign against keeping dogs chained, in the belief that chained dogs are more likely to be bitten by rabid animals because they cannot escape, and are in turn more likely to bite a person who is perceived as a threat, again because they cannot run away. These beliefs were validated by behavioral research more than 90 years later.
The last human death from canine rabies in Great Britain occurred in Wales in 1902, but canine rabies persisted among dogs for 20 years longer. Canine rabies was finally eradicated from Great Britain after NCDL clinics became the leading providers of canine rabies vaccination nationwide, a paradox in view that Stock and friends had stalwartly opposed vaccination in the mistaken belief that it was a vivisectionist hoax.
Jamaka Petzak says
Educational. Sharing with gratitude.